![]() ![]() The first studies with these biologics in CRSwNP have shown promising results and a positive impact on quality of life. Omalizumab and other biologics (anti-IL5, anti-IL5R, and anti-Il4Rα) are effective for the treatment of asthma with a type 2 inflammatory signature. However, type 2 inflammation-targeting biologics have entered the market for selected pheno/endotypes of asthma and may soon become available for CRSwNP patients. The goal of CRSwNP management is clinical control with minimal use of medication or surgery, but this is challenging. When symptoms are persistent or when there is a long-term need for antibiotics or systemic steroids, it is considered uncontrolled disease. ĬRSwNP severely impacts quality of life and has a significant burden on society. It is frequently comorbid with asthma and both diseases share common underlying pathophysiological mechanisms driving the disease, including type 2 inflammation. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition of the sinonasal cavities. ![]()
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